New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in BacteriaReportar como inadecuado


New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria


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1

Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary

2

Travel Medicine, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-008 Lisbon, Portugal





*

Author to whom correspondence should be addressed.



Academic Editor: Maria Emília de Sousa

Abstract Multidrug resistance MDR has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials. This inappropriate application and mismanagement of antibiotics have led to serious problems in the therapy of infectious diseases. Bacteria can develop resistance by various mechanisms and one of the most important factors resulting in MDR is efflux pump-mediated resistance. Because of the importance of the efflux-related multidrug resistance the development of new therapeutic approaches aiming to inhibit bacterial efflux pumps is a promising way to combat bacteria having over-expressed MDR efflux systems. The definition of an efflux pump inhibitor EPI includes the ability to render the bacterium increasingly more sensitive to a given antibiotic or even reverse the multidrug resistant phenotype. In the recent years numerous EPIs have been developed, although so far their clinical application has not yet been achieved due to their in vivo toxicity and side effects. In this review, we aim to give a short overview of efflux mediated resistance in bacteria, EPI compounds of plant and synthetic origin, and the possible methods to investigate and screen EPI compounds in bacterial systems. View Full-Text

Keywords: multidrug resistance; multidrug efflux pump; efflux pump inhibitor EPI; proton motive force; RND pump; ABC-transporter multidrug resistance; multidrug efflux pump; efflux pump inhibitor EPI; proton motive force; RND pump; ABC-transporter





Autor: Gabriella Spengler 1,* , Annamária Kincses 1, Márió Gajdács 1 and Leonard Amaral 1,2

Fuente: http://mdpi.com/



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