Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory MediatorsReportar como inadecuado


Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators


Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt

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Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain-Helwan, Helwan 11795, Cairo, Egypt

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Department of Chemistry and Biochemistry, Concordia University, 7141 rue Sherbrooke O., Montréal, H4Bm1R6 QC, Canada

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Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza-Egypt, Giza 12211, Egypt

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Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza-Egypt, Giza 12211, Egypt





*

Author to whom correspondence should be addressed.



Academic Editor: Diego Muñoz-Torrero

Abstract A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, 1H-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site. View Full-Text

Keywords: pyrroles; pyrrolopyridines; synthesis; anti-inflammatory assay; cytokine inhibitors; docking study pyrroles; pyrrolopyridines; synthesis; anti-inflammatory assay; cytokine inhibitors; docking study





Autor: Samar Said Fatahala 1,* , Sherifa Hasabelnaby 2,3, Ayman Goudah 4, Ghada I. Mahmoud 5 and Rania Helmy Abd-El Hameed 1

Fuente: http://mdpi.com/



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