Catechins and Their Therapeutic Benefits to Inflammatory Bowel DiseaseReportar como inadecuado


Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease


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1

Department of Gastroenterology, First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, China

2

Department of Geriatrics, First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, China





*

Authors to whom correspondence should be addressed.



Academic Editor: Derek J. McPhee

Abstract Catechins are natural polyphenolic phytochemicals that exist in food and medicinal plants, such as tea, legume and rubiaceae. An increasing number of studies have associated the intake of catechins-rich foods with the prevention and treatment of chronic diseases in humans, such as inflammatory bowel disease IBD. Some studies have demonstrated that catechins could significantly inhibit the excessive oxidative stress through direct or indirect antioxidant effects and promote the activation of the antioxidative substances such as glutathione peroxidases GPO and glutathione GSH, reducing the oxidative damages to the colon. In addition, catechins can also regulate the infiltration and proliferation of immune related-cells, such as neutrophils, colonic epithelial cells, macrophages, and T lymphocytes, helping reduce the inflammatory relations and provide benefits to IBD. Perhaps catechins can further inhibit the deterioration of intestinal lesions through regulating the cell gap junctions. Furthermore, catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways, such as nuclear factor-kappa B NF-κB, mitogen activated protein kinases MAPKs, transcription factor nuclear factor erythroid-derived 2-like 2 Nrf2, signal transducer and the activator of transcription 1-3 STAT1-3 pathways. Finally, catechins can also stabilize the structure of the gastrointestinal micro-ecological environment via promoting the proliferation of beneficial intestinal bacteria and regulating the balance of intestinal flora, so as to relieve the IBD. Furthermore, catechins may regulate the tight junctions TJ in the epithelium. This paper elaborates the currently known possible molecular mechanisms of catechins in favor of IBD. View Full-Text

Keywords: catechins; inflammatory bowel disease; oxidative stress; mechanisms; tight junction functionality catechins; inflammatory bowel disease; oxidative stress; mechanisms; tight junction functionality





Autor: Fei-Yan Fan 1, Li-Xuan Sang 2,* and Min Jiang 1,*

Fuente: http://mdpi.com/



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