The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1-Th2 Cytokine BalanceReportar como inadecuado


The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1-Th2 Cytokine Balance


The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1-Th2 Cytokine Balance - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

2

Department of Liver disease, Army General Hospital of PLA, Beijing 100700, China

3

Department of Pharmacy, Changji Vocational and Technical College, Changji 831100, China

4

Xinjiang Jinshikang Pharmaceutical Co., Ltd., Urumchi 830000, China





*

Author to whom correspondence should be addressed.



Academic Editor: Maurizio Battino

Abstract Shenqi is a traditional Chinese polyherbal medicine has been widely used for the treatment of allergic rhinitis AR. The aim of this study was to investigate the anti-allergic rhinitis activity of Shenqi and explore its underlying molecular mechanism. Ovalbumin OVA-induced allergic rhinitis rat model was used to evaluate the anti-allergic rhinitis effect of Shenqi. The effect of Shenqi on IgE-mediated degranulation was measured using rat basophilic leukemia RBL-2H3 cells. Primary spleen lymphocytes were isolated to investigate the anti-allergic mechanism of Shenqi by detecting the expression of transcription factors via Western blot and the level of cytokines IL-4 and IFN-γ via ELISA. In OVA-induced AR rat models, Shenqi relieved the allergic rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and reduced the levels of IL-4 and IgE. The results from the in vitro study certified that Shenqi inhibited mast cell degranulation. Furthermore, the results of GATA3, T-bet, p-STAT6, and SOCS1 expression and production of IFN-γ and IL-4 demonstrated that Shenqi balanced the ratio of Th1-Th2 IFN-γ-IL-4 in OVA-stimulated spleen lymphocytes. In conclusion, these results suggest that Shenqi exhibits an obvious anti-allergic effect by suppressing the mast cell-mediated allergic response and by improving the imbalance of Th1-Th2 ratio in allergic rhinitis. View Full-Text

Keywords: allergic rhinitis; anti-allergic activity; Shenqi; degranulation; Th1-Th2 balance allergic rhinitis; anti-allergic activity; Shenqi; degranulation; Th1-Th2 balance





Autor: Yang-Yang Shao 1, Yi-Ming Zhou 2, Min Hu 1, Jin-Ze Li 1, Cheng-Juan Chen 1, Yong-Jiang Wang 3, Xiao-Yun Shi 4, Wen-Jie Wang 1 and Tian-Tai Zhang 1,*

Fuente: http://mdpi.com/



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