Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan DerivativesReportar como inadecuado


Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives


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1

Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China

2

University of Chinese Academy of Sciences, Beijing 100049, China





*

Authors to whom correspondence should be addressed.



Academic Editors: Luciano Saso, László Dux, Grzegorz Wegrzyn and Tamás Csont

Abstract With the specialty of improving the water solubility of chitosan, quaternary ammonium salts have broadened the application of this polysaccharide in food, medicine and pesticides. To identify the effect of quaternary ammonium salts’ quantity, single quaternized chitosan N-phenmethyl-N,N-dimethyl chitosan PDCS, double quaternized chitosan N-1-pyridylmethyl-2-ylmethyl-N,N-dimethyl chitosan MP2MDCS, N-1-pyridylmethyl-3-ylmethyl-N,N-dimethyl chitosan MP3MDCS, and N-1-pyridylmethyl-4-ylmethyl-N,N-dimethyl chitosan MP4MDCS were designed and synthesized successfully through chemical modification of chitosan. Besides, three kinds of antioxidant activities, including hydroxyl radicals, superoxide radicals, and 1,1-Diphenyl-2-picrylhydrazyl DPPH radicals were tested in vitro. As shown in this paper, the scavenging ability was ranking in order of MP3MDC > MP4MDCS > MP2MDCS > PDCS > chitosan at 1.6 mg-mL in all assays. All double quaternary ammonium salts were better than chitosan or the single quaternary ammonium salt. In addition, MP3MDCS could scavenge hydroxyl radicals totally at 1.6 mg-mL. MP2MDCS and MP4MDCS with more than 90% scavenging indices both had great scavenging ability on hydroxyl radicals or DPPH radicals. Furthermore, these data demonstrated that the increasing number of the positive charge would improve the antioxidant property of chitosan derivatives, and the N-pyridinium position would influence the scavenging radical ability. View Full-Text

Keywords: single quaternized chitosan; double quaternized chitosan; chemical modification; antioxidant activity single quaternized chitosan; double quaternized chitosan; chemical modification; antioxidant activity





Autor: Lijie Wei 1,2, Qing Li 1,* , Wenqiang Tan 1,2, Fang Dong 1, Fang Luan 1,2 and Zhanyong Guo 1,2,*

Fuente: http://mdpi.com/



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