Solanesol Biosynthesis in PlantsReportar como inadecuado

Solanesol Biosynthesis in Plants

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Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China


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Academic Editor: Derek J. McPhee

Abstract Solanesol is a non-cyclic terpene alcohol composed of nine isoprene units that mainly accumulates in solanaceous plants. Solanesol plays an important role in the interactions between plants and environmental factors such as pathogen infections and moderate-to-high temperatures. Additionally, it is a key intermediate for the pharmaceutical synthesis of ubiquinone-based drugs such as coenzyme Q10 and vitamin K2, and anti-cancer agent synergizers such as N-solanesyl-N,N′-bis3,4-dimethoxybenzyl ethylenediamine SDB. In plants, solanesol is formed by the 2-C-methyl-d-erythritol 4-phosphate MEP pathway within plastids. Solanesol’s biosynthetic pathway involves the generation of C5 precursors, followed by the generation of direct precursors, and then the biosynthesis and modification of terpenoids; the first two stages of this pathway are well understood. Based on the current understanding of solanesol biosynthesis, we here review the key enzymes involved, including 1-deoxy-d-xylulose 5-phosphate synthase DXS, 1-deoxy-d-xylulose 5-phosphate reductoisomerase DXR, isopentenyl diphosphate isomerase IPI, geranyl geranyl diphosphate synthase GGPPS, and solanesyl diphosphate synthase SPS, as well as their biological functions. Notably, studies on microbial heterologous expression and overexpression of key enzymatic genes in tobacco solanesol biosynthesis are of significant importance for medical uses of tobacco. View Full-Text

Keywords: solanesol; function; biosynthetic pathway; key enzymes solanesol; function; biosynthetic pathway; key enzymes

Autor: Ning Yan * , Yanhua Liu, Hongbo Zhang, Yongmei Du, Xinmin Liu and Zhongfeng Zhang



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