R-7-Azepan-3-ylamino-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid HydrochlorideReportar como inadecuado


R-7-Azepan-3-ylamino-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride


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R&D Center, Jiangsu Yabang Pharmaceutical Group, Changzhou 213200, China





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Abstract In this paper R-7-azepan-3-ylamino-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride 1 was isolated and identified as the N-substituted regioisomer of besifloxacin, which has been synthesized from the reaction of 8-chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 3 with R-tert-butyl 3-aminoazepane-1-carboxylate 2 in acetonitrile as solvent in 37% yield. The chemical structure of compound 1 was established on the basis of 1H-NMR, 13C-NMR, mass spectrometry data and elemental analysis. View Full-Text

Keywords: besifloxacin; N-substituted regioisomer besifloxacin; N-substituted regioisomer





Autor: Zhengjun Xia, Zaixin Chen * and Shuitao Yu

Fuente: http://mdpi.com/



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