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Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, D-38106 Braunschweig, Germany


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Abstract The indole ring system is a prominent partial structure of several protein kinase inhibitor families. The title compound is the first example of a 5-substituted indolyl squaryl chloride with free indole nitrogen. It has been synthesized by reaction of 5-methoxyindole with squaric acid dichloride in diethyl ether and its IR, 1H-NMR, 13C-NMR, MS, UV and HPLC data are presented. This compound may prove to be a rather useful building block for the preparation of various derivatives for biological studies. View Full-Text

Keywords: Friedel-Crafts acylation; indole; squaric acid dichloride Friedel-Crafts acylation; indole; squaric acid dichloride

Autor: Duc Hoàng Lande, Marleen Messal, Vincent Reimann, Caren Renger, Constanze Rurka, Jana Schoemaker, Nadin K. Schröder and Johann Grünefeld *

Fuente: http://mdpi.com/


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