2,3,4,9-Tetrahydro-9-3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl-8-methoxy-3,3-dimethyl-1H-xanthen-1-oneReportar como inadecuado


2,3,4,9-Tetrahydro-9-3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl-8-methoxy-3,3-dimethyl-1H-xanthen-1-one


2,3,4,9-Tetrahydro-9-3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl-8-methoxy-3,3-dimethyl-1H-xanthen-1-one - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

School of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe, 650-8530, Japan





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Abstract The title compound 2,3,4,9-tetrahydro-9-3-hydroxy-1,4-dioxo-1H-dihydro-naphthalen-2-yl-8-methoxy-3,3-dimethyl-1H-xanthen-1-one 5 was obtained by the nucleophilic addition of 2-hydroxy-1,4-naphthoquinone 4 to 2H-chromene derivative 3, which was prepared by the domino three-component coupling reaction of aryne precursor 1 with DMF and the active methylene compound dimedone 2. The one-pot synthesis of the title compound 5 from aryne precursor 1 was also achieved. View Full-Text

Keywords: multi-component reaction; domino reaction; arynes; heterocycles; synthesis multi-component reaction; domino reaction; arynes; heterocycles; synthesis





Autor: Eito Yoshioka, Shigeru Kohtani and Hideto Miyabe *

Fuente: http://mdpi.com/



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