An Integrated Glucose Sensor with an All-Solid-State Sodium Ion-Selective Electrode for a Minimally Invasive Glucose Monitoring SystemReportar como inadecuado




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Central Research Laboratories, Sysmex Corporation, 4-4-4 Takatsukadai, Nishi-ku, Kobe, Hyogo 651-2271, Japan





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Academic Editors: Kazunori Hoshino and Emmanuel Quevy

Abstract We developed a minimally invasive glucose monitoring system that uses a microneedle to permeate the skin surface and a small hydrogel to accumulate interstitial fluid glucose. The measurement of glucose and sodium ion levels in the hydrogel is required for estimating glucose levels in blood; therefore, we developed a small, enzyme-fixed glucose sensor with a high-selectivity, all-solid-state, sodium ion-selective electrode ISE integrated into its design. The glucose sensor immobilized glucose oxidase showed a good correlation between the glucose levels in the hydrogels and the reference glucose levels r > 0.99, and exhibited a good precision coefficient of variation = 2.9%, 0.6 mg-dL. In the design of the sodium ISEs, we used the insertion material Na0.33MnO2 as the inner contact layer and DD16C5 exhibiting high Na+-K+ selectivity as the ionophore. The developed sodium ISE exhibited high selectivity \ \log \,k^{pot} {Na,K} = -2.8\ and good potential stability. The sodium ISE could measure 0.4 mM 10−3.4 M sodium ion levels in the hydrogels containing 268 mM 10−0.57 M KCl. The small integrated sensor ϕ < 10 mm detected glucose and sodium ions in hydrogels simultaneously within 1 min, and it exhibited sufficient performance for use as a minimally invasive glucose monitoring system. View Full-Text

Keywords: all-solid-state; sodium ion sensor; ion-selective electrode ISE; glucose sensor; diabetes mellitus; interstitial fluid; minimally invasive glucose monitoring all-solid-state; sodium ion sensor; ion-selective electrode ISE; glucose sensor; diabetes mellitus; interstitial fluid; minimally invasive glucose monitoring





Autor: Junko Kojima * , Samiko Hosoya, Chihiro Suminaka, Nobuyasu Hori and Toshiyuki Sato

Fuente: http://mdpi.com/



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