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Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430000, China

Both authors contributed equally to this work.


Author to whom correspondence should be addressed.

Academic Editors: Andrew deMell and Xavier Casadevall i Solvas

Abstract A microfluidic droplet mixer is developed for rapid detection of HgII ions. Reagent concentration and droplets can be precisely controlled by adjusting the flow rates of different fluid phases. By selecting suitable flow rates of the oil phase, probe phase and sample phase, probe droplets and sample droplets can be matched and merged in pairs and subsequently well-mixed in the poly dimethylsiloxane PDMS channels. The fluorescence enhancement probe Rhodamine B mixed with gold nanoparticles encapsulated in droplets can react with HgII ions. The HgII ion concentration in the sample droplets is adjusted from about 0 to 1000 nM through fluid regulation to simulate possible various contaminative water samples. The intensity of the emission fluorescence is sensitive to HgII ions increases as the HgII ion concentration increases. Through the analysis of the acquired fluorescence images, the concentration of HgII ions can be precisely detected. With the advantages of less time, cost consumption and easier manipulations, this device would have a great potential in micro-scale sample assays and real-time chemical reaction studies. View Full-Text

Keywords: microfluidic; droplet; mixer; HgII ion; gold nanoparticle microfluidic; droplet; mixer; HgII ion; gold nanoparticle

Autor: Qian-Fang Meng †, Lang Rao †, Bo Cai, Su-Jian You, Shi-Shang Guo, Wei Liu * and Xing-Zhong Zhao

Fuente: http://mdpi.com/


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