Compositional Variation and Bioactivity of the Leaf Essential Oil of Montanoa guatemalensis from Monteverde, Costa Rica: A Preliminary InvestigationReportar como inadecuado




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Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA





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Academic Editor: Satyajit D. Sarker

Abstract Background: Montanoa guatemalensis is a small to medium-sized tree in the Asteraceae that grows in Central America from Mexico south through Costa Rica. There have been no previous investigations on the essential oil of this tree. Methods: The leaf essential oils of M. guatemalensis were obtained from different individual trees growing in Monteverde, Costa Rica, in two different years, and were analyzed by gas chromatography—mass spectrometry. Results: The leaf oils from 2008 were rich in sesquiterpenoids, dominated by α-selinene, β-selinene, and cyclocolorenone, with lesser amounts of the monoterpenes α-pinene and limonene. In contrast, the samples from 2009 showed no α- or β-selinene, but large concentrations of trans-muurola-414,5-diene, β-cadinene, and cyclocolorenone, along with greater concentrations of α-pinene and limonene. The leaf oils were screened for cytotoxic and antimicrobial activities and did show selective cytotoxic activity on MDA-MB-231 breast tumor cells. Conclusion: M. guatemalensis leaf oil, rich in cyclocolorenone, α-selinene, and β-selinene, showed selective in vitro cytotoxic activity to MDA-MB-231 cells. The plant may be a good source of cyclocolorenone. View Full-Text

Keywords: essential oil composition; cyclocolorenone; selinene; muuroladiene; cadinene; limonene; pinene; cytotoxicity essential oil composition; cyclocolorenone; selinene; muuroladiene; cadinene; limonene; pinene; cytotoxicity





Autor: Victoria D. Flatt, Carlos R. Campos, Maria P. Kraemer, Brittany A. Bailey, Prabodh Satyal and William N. Setzer *

Fuente: http://mdpi.com/



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