Characterization and Antimicrobial Activity of Volatile Constituents from Fresh Fruits of Alchornea cordifolia and Canthium subcordatumReportar como inadecuado




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1

Department of Chemistry, University of Uyo, Akwa Ibom State 520101, Nigeria

2

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

3

Department of Chemistry, University of Ibadan, Ibadan 200284, Nigeria





*

Author to whom correspondence should be addressed.



Academic Editors: Lutfun Nahar, Norazah Basar and Satyajit D. Sarker

Abstract Bacterial resistance has been increasingly reported worldwide and is one of the major causes of failure in the treatment of infectious diseases. Natural-based products, including plant secondary metabolites phytochemicals, can be exploited to ameliorate the problem of microbial resistance. The fruit essential oils of Alchornea cordifolia and Canthium subcordatum were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry GC-MS. The essential oils were subjected to in vitro antibacterial, antifungal and cytotoxic activity screening. Thirty-eight compounds comprising 97.7% of A. cordifolia oil and forty-six constituents representing 98.2% of C. subcordatum oil were identified. The major components in A. cordifolia oil were methyl salicylate 25.3%, citronellol 21.4%, α-phellandrene 7.4%, terpinolene 5.7% and 1,8-cineole 5.5%. Benzaldehyde 28.0%, β-caryophyllene 15.5%, E,E-α-farnesene 5.3% and methyl salicylate 4.5% were the quantitatively significant constituents in C. subcordatum fruit essential oil. A. cordifolia essential oil demonstrated potent in vitro antibacterial activity against Staphylococcus aureus MIC = 78 μg-mL and marginal antifungal activity against Aspergillus niger MIC = 156 μg-mL. C. subcordatum showed antibacterial activity against Bacillus cereus and S. aureus MIC = 156 μg-mL and notable antifungal activity against A. niger MIC = 39 μg-mL. However, no appreciable cytotoxic effects on human breast carcinoma cells Hs 578T and human prostate carcinoma cells PC-3 were observed for either essential oil. The antimicrobial activities of A. cordifolia and C. subcordatum fruit essential oils are a function of their distinct chemical profiles; their volatiles and biological activities are reported for the first time. View Full-Text

Keywords: Alchornea cordifolia; Canthium subcordatum; essential oil composition; antibacterial; antifungal Alchornea cordifolia; Canthium subcordatum; essential oil composition; antibacterial; antifungal





Autor: Emmanuel E. Essien 1,* , Jennifer Schmidt Newby 2, Tameka M. Walker 2, William N. Setzer 2 and Olusegun Ekundayo 3

Fuente: http://mdpi.com/



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