Heteromeles Arbutifolia, a Traditional Treatment for Alzheimer’s Disease, Phytochemistry and SafetyReportar como inadecuado




Heteromeles Arbutifolia, a Traditional Treatment for Alzheimer’s Disease, Phytochemistry and Safety - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China

2

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90899-9121, USA





*

Author to whom correspondence should be addressed.



Academic Editor: Gerhard Litscher

Abstract Background: This study examined the chemistry and safety of Heteromeles arbutifolia, also called toyon or California holly, which is a traditional California Indian food and treatment for Alzheimer’s disease. Methods: Plant extracts were examined by HPLC-MS, NMR and other techniques to identify compounds. Volunteers were recruited to examine the acute safety of the plant medicine using a standard short-term memory test. Results: The plant was found to contain icariside E4, dihydroxyoleanenoic acid, maslinic acid, betulin, trihydroxyoxo-seco-ursdienoic acid, catechin, vicenin-2, farrerol, kaempferide and tetrahydroxyoleanenoic acid. These compounds are anti-inflammatory agents that may protect the blood-brain barrier and prevent inflammatory cell infiltration into the brain. The dried berries were ingested by six volunteers to demonstrate the safety of the medicine. Conclusion: The plant medicine was found to contain several compounds that may be of interest in the treatment of Alzheimer’s disease. The plant medicine was found to be safe. View Full-Text

Keywords: Heteromeles arbutifolia; toyon; California holly; Alzheimer’s disease; phytochemistry; safety Heteromeles arbutifolia; toyon; California holly; Alzheimer’s disease; phytochemistry; safety





Autor: Xiaogang Wang 1, Raphael Dubois 2, Caitlyn Young 2, Eric J. Lien 2 and James D. Adams 2,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados