Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-CyclodextrinReportar como inadecuado




Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama 350-0295, Japan





*

Author to whom correspondence should be addressed.



Academic Editor: Carsten Werner

Abstract We have designed a sugar-responsive pseudopolyrotaxane PPRX by combining phenylboronic acid-modified polyethylene glycol PBA–PEG and γ-cyclodextrin. Phenylboronic acid PBA was used as a sugar-recognition motif in the PPRX because PBA reacts with a diol portion of the sugar molecule and forms a cyclic ester. When D-fructose or D-glucose was added to a suspension of PPRX, PPRX disintegrated, depending on the concentration of the sugars. Interestingly, catechol does not show a response although catechol has a high affinity for PBA. We analyzed the response mechanism of PPRX by considering equilibria. View Full-Text

Keywords: pseudopolyrotaxane; cyclodextrin; boronic acid; drug delivery; stimuli-responsive material pseudopolyrotaxane; cyclodextrin; boronic acid; drug delivery; stimuli-responsive material





Autor: Tomohiro Seki, Misato Namiki, Yuya Egawa * , Ryotaro Miki, Kazuhiko Juni and Toshinobu Seki

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados