Medium-Term Function of a 3D Printed TCP-HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 ActivationReportar como inadecuado




Medium-Term Function of a 3D Printed TCP-HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Division of Fixed Prosthodontics and Biomaterials, University of Geneva, University Clinics of Dental Medicine, 19, rue Barthélemy-Menn, Geneva 1205, Switzerland

2

Department of Maxillofacial and Oral Surgery, Division of Oral and Maxillofacial Pathology HUG, University Clinics of Dental Medicine, 19, rue Barthélemy-Menn, Geneva 1205, Switzerland





*

Author to whom correspondence should be addressed.



Academic Editor: Naozumi Teramoto

Abstract Introduction: A 3D-printed construct made of orthogonally layered strands of tricalcium phosphate TCP and hydroxyapatite has recently become available. The material provides excellent osteoconductivity. We simulated a medium-term experiment in a sheep calvarial model by priming the blocks with BMP-2. Vertical bone growth-maturation and material resorption were evaluated. Materials and methods: Titanium hemispherical caps were filled with either bare- or BMP-2 primed constructs and placed onto the calvaria of adult sheep n = 8. Histomorphometry was performed after 8 and 16 weeks. Results: After 8 weeks, relative to bare constructs, BMP-2 stimulation led to a two-fold increase in bone volume Bare: 22% ± 2.1%; BMP-2 primed: 50% ± 3% and a 3-fold decrease in substitute volume Bare: 47% ± 5%; BMP-2 primed: 18% ± 2%. These rates were still observed at 16 weeks. The new bone grew and matured to a haversian-like structure while the substitute material resorbed via cell- and chemical-mediation. Conclusion: By priming the 3D construct with BMP-2, bone metabolism was physiologically accelerated, that is, enhancing vertical bone growth and maturation as well as material bioresorption. The scaffolding function of the block was maintained, leaving time for the bone to grow and mature to a haversian-like structure. In parallel, the material resorbed via cell-mediated and chemical processes. These promising results must be confirmed in clinical tests. View Full-Text

Keywords: bone substitute block; 3D-printing; BMP-2; animal experiments; guided tissue regeneration; bone regeneration bone substitute block; 3D-printing; BMP-2; animal experiments; guided tissue regeneration; bone regeneration





Autor: Mira Moussa 1, Jean-Pierre Carrel 2, Susanne Scherrer 1, Maria Cattani-Lorente 1, Anselm Wiskott 1 and Stéphane Durual 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados