A Sterol and Spiroditerpenoids from a Penicillium sp. Isolated from a Deep Sea Sediment SampleReportar como inadecuado




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1

Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China

2

Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen 361005, China





*

Authors to whom correspondence should be addressed.



Abstract A new polyoxygenated sterol, sterolic acid 1, three new breviane spiroditerpenoids, breviones I–K 2–4, and the known breviones 5–8, were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 1–4 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin. View Full-Text

Keywords: Penicillium sp.; deep sea sediment; sterol; spiroditerpenoids; cytotoxicity Penicillium sp.; deep sea sediment; sterol; spiroditerpenoids; cytotoxicity





Autor: Yan Li 1, Dezan Ye 2, Zongze Shao 2, Chengbin Cui 1,* and Yongsheng Che 1,*

Fuente: http://mdpi.com/



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