Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal WatersReportar como inadecuado




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1

Department of Public Health Sciences, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA

2

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Wuhan University, Ministry of Education, and Institute of Traditional Chinese Medicine & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China

3

Center for Marine Microbial Ecology and Diversity, University of Hawaii at Manoa, Honolulu, HI 96822, USA

4

Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA





*

Authors to whom correspondence should be addressed.



Abstract Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including many endemic species. Thirty-eight microbial extracts from Hawaiian coastal waters were evaluated for their antiviral activity against four mammalian viruses including herpes simplex virus type one HSV-1, vesicular stomatitis virus VSV, vaccinia virus and poliovirus type one poliovirus-1 using in vitro cell culture assay. Nine of the 38 microbial crude extracts showed antiviral potencies and three of these nine microbial extracts exhibited significant activity against the enveloped viruses. A secosteroid, 5αH,17αH,20R-beta-acetoxyergost-814-ene was putatively identified and confirmed to be the active compound in these marine microbial extracts. These results warrant future in-depth tests on the isolation of these active elements in order to explore and validate their antiviral potential as important therapeutic remedies. View Full-Text

Keywords: marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids marine extract; antiviral drug; antiviral activity; enveloped virus; secosteroids





Autor: Jing Tong 1,2, Hank Trapido-Rosenthal 3, Jun Wang 4, Youwei Wang 2, Qing X. Li 4,* and Yuanan Lu 1,*

Fuente: http://mdpi.com/



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