Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocauleReportar como inadecuado




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1

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

2

National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan

3

Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan

4

Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan

5

National Research Institute of Chinese Medicine, Taipei 112, Taiwan

6

Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan





*

Author to whom correspondence should be addressed.



Abstract Three new cembranoids, sarcocrassocolides M–O 1–3, have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1–3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. View Full-Text

Keywords: soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity soft coral; Sarcophyton crassocaule; cytotoxic activity; anti-inflammatory activity





Autor: Wan-Yu Lin 1, Yi Lu 1, Bo-Wei Chen 1, Chiung-Yao Huang 1, Jui-Hsin Su 2,3, Zhi-Hong Wen 1, Chang-Feng Dai 4, Yao-Haur Kuo 5 and Jyh-Horng Sheu 1,6,*

Fuente: http://mdpi.com/



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