Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.Reportar como inadecuado




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1

School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China

2

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China





*

Author to whom correspondence should be addressed.



Abstract The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E 1–5, and the known sesquiterpenoid hirsutanol C 6, were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A 1 showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 μM, respectively. View Full-Text

Keywords: Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities Chondrostereum sp.; sesquiterpenoids; chondrosterins; marine fungus; cytotoxic activities





Autor: Hou-Jin Li 1, Ying-Lu Xie 1, Zhong-Liang Xie 2, Ying Chen 1, Chi-Keung Lam 1 and Wen-Jian Lan 2,*

Fuente: http://mdpi.com/



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