First Total Synthesis of a Naturally Occurring Iodinated 5′-Deoxyxylofuranosyl Marine NucleosideReportar como inadecuado




First Total Synthesis of a Naturally Occurring Iodinated 5′-Deoxyxylofuranosyl Marine Nucleoside - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science Technology Normal University, Nanchang 330013, China





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Abstract 4-Amino-7-5′-deoxy-β-d-xylofuranosyl-5-iodo-pyrrolo2,3-dpyrimidine 1, an unusual naturally occurring marine nucleoside isolated from an ascidan, Diplosoma sp., was synthesized from d-xylose in seven steps with 28% overall yield on 10 g scale. The key step was Vorbrüggen glycosylation of 5-iodo-pyrrolo2,3-dpyrimidine with 5-deoxy-1, 2-O-diacetyl-3-O-benzoyl-d-xylofuranose. Its absolute configuration was confirmed. View Full-Text

Keywords: Vorbrüggen glycosylation; total synthesis; pyrrolo2,3-dpyrimidine; marine nucleoside Vorbrüggen glycosylation; total synthesis; pyrrolo2,3-dpyrimidine; marine nucleoside





Autor: Jianyun Sun, Yanhui Dou, Haixin Ding, Ruchun Yang, Qi Sun and Qiang Xiao *

Fuente: http://mdpi.com/



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