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National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan


Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan


Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan


Institute of Marine Biology, National Sun Yat-sen University, Kaohsiung 804, Taiwan


Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan


Eastern Marine Biology Research Center, Fisheries Research Institute, Taitung 961, Taiwan


Author to whom correspondence should be addressed.

Abstract One new pentacyclic sesterterpene, hippospongide A 1, and one new scalarane sesterterpenoid, hippospongide B 2, along with six previously reported known scalarane–type sesterterpenes 3–8, were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3–5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines. View Full-Text

Keywords: sesterterpenoid; scalarane; sponge; Hippospongia sesterterpenoid; scalarane; sponge; Hippospongia

Autor: Yu-Chia Chang 1,2, Shang-Wei Tseng 1,3, Li-Lian Liu 4,5, Yalan Chou 4, Yuan-Shing Ho 6, Mei-Chin Lu 1,3 and Jui-Hsin Su 1,3,5,*



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