Anti-Oxidative, Anti-Tumor-Promoting, and Anti-Carcinogensis Activities of Nitroastaxanthin and Nitrolutein, the Reaction Products of Astaxanthin and Lutein with PeroxynitriteReportar como inadecuado




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1

Research Institute for Production Development, 15 Shimogamo-morimoto-cho, Sakyo-ku, Kyoto 606-0805, Japan

2

Department of Complementary and Alternative Medicine, Clinical R&D, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan

3

Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan





*

Author to whom correspondence should be addressed.



Abstract Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin showed excellent singlet oxygen quenching activity. Furthermore, 15-nitroastaxanthin showed inhibitory effects of in vitro Epstein-Barr virus early antigen activation and two-stage carcinogensis on mouse skin papillomas. These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite. View Full-Text

Keywords: carotenoid; 15-nitroastaxanthin; 15-nitrolutein; anti-carcinogensis activity; anti-oxidative activity carotenoid; 15-nitroastaxanthin; 15-nitrolutein; anti-carcinogensis activity; anti-oxidative activity





Autor: Takashi Maoka 1,* , Harukuni Tokuda 2, Nobutaka Suzuki 2, Hideaki Kato 3 and Hideo Etoh 3

Fuente: http://mdpi.com/



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