Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosaReportar como inadecuado




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1

Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

2

College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

3

Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, Shanghai 200438, China





*

Authors to whom correspondence should be addressed.



Abstract Seven new formamido-diterpenes, cavernenes A–D 1–4, kalihinenes E and F 5–6, and kalihipyran C 7, together with five known compounds 8–12, were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231 with IC50 values in the range of 6–18 μM. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 μg-mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, Cryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 μg-mL, respectively. View Full-Text

Keywords: Acanthella cavernosa; formamido-diterpenes; cytotoxicity; antifungal activity Acanthella cavernosa; formamido-diterpenes; cytotoxicity; antifungal activity





Autor: Ying Xu 1,2, Jun-Hui Lang 1, Wei-Hua Jiao 1, Ru-Ping Wang 1,2, Ying Peng 2, Shao-Jiang Song 2,* , Bao-Hua Zhang 3,* and Hou-Wen Lin 1,*

Fuente: http://mdpi.com/



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