Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.Reportar como inadecuado




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1

Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea

2

Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea

3

Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea





*

Authors to whom correspondence should be addressed.



Abstract Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS-MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities. View Full-Text

Keywords: Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity Haliclona sp.; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity





Autor: Yoonyeong Lee 1, Kyoung Hwa Jang 1, Ju-eun Jeon 1, Woo-Young Yang 2, Chung J. Sim 3, Ki-Bong Oh 2,* and Jongheon Shin 1,*

Fuente: http://mdpi.com/



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