Anti-Allergic Compounds from the Deep-Sea-Derived Actinomycete Nesterenkonia flava MCCC 1K00610Reportar como inadecuado


Anti-Allergic Compounds from the Deep-Sea-Derived Actinomycete Nesterenkonia flava MCCC 1K00610


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1

State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen 361005, China

2

Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China

3

College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 36102, China





*

Author to whom correspondence should be addressed.



Academic Editor: Valeria Costantino

Abstract A novel cyclic ether, nesterenkoniane 1, was isolated from the deep-sea-derived actinomycete Nesterenkonia flava MCCC 1K00610, together with 12 known compounds, including two macrolides 2, 3, two diketopiperazines 4, 5, two nucleosides 6, 7, two indoles 8, 9, three phenolics 10–12, and one butanol derivate 13. Their structures were established mainly on detailed analysis of the NMR and MS spectroscopic data. All 13 compounds were tested for anti-allergic activities using immunoglobulin E IgE mediated rat mast RBL-2H3 cell model. Under the concentration of 20 μg-mL, 1 exhibited moderate anti-allergic activity with inhibition rate of 9.86%, compared to that of 37.41% of the positive control, loratadine. While cyclod-Pro-d-Leu 4 and indol-3-carbaldehyde 8 showed the most potent effects with the IC50 values of 69.95 and 57.12 μg-mL, respectively, which was comparable to that of loratadine IC50 = 35.01 μg-mL. To the best of our knowledge, it is the first report on secondary metabolites from the genus of Nesterenkonia. View Full-Text

Keywords: actinomycetes; Nesterenkonia; deep-sea; food allergy actinomycetes; Nesterenkonia; deep-sea; food allergy





Autor: Chun-Lan Xie 1,2, Qingmei Liu 3, Jin-Mei Xia 1, Yuanyuan Gao 3, Quan Yang 2, Zong-Ze Shao 1, Guangming Liu 3 and Xian-Wen Yang 1,*

Fuente: http://mdpi.com/



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