Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegansReportar como inadecuado


Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans


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School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China





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Academic Editors: Kirsten Benkendorff and Vassilios Roussis

Abstract Two novel biscembranoids, sarelengans A and B 1 and 2, five new cembranoids, sarelengans C–G 3–7, along with two known cembranoids 8 and 9 were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A-B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆8 rather than the normal cembranoid-∆1 unit in the endo-Diels-Alder cycloaddition. Compounds 2 and 3 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC50 values being at 18.2 and 32.5 μM, respectively. View Full-Text

Keywords: Sarcophyton elegans; biscembranoids; cembranoids; NO inhibition Sarcophyton elegans; biscembranoids; cembranoids; NO inhibition





Autor: Wei Li, Yi-Hong Zou, Man-Xi Ge, Lan-Lan Lou, Yun-Shao Xu, Abrar Ahmed, Yun-Yun Chen, Jun-Sheng Zhang, Gui-Hua Tang and Sheng Yin *

Fuente: http://mdpi.com/



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