An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.Reportar como inadecuado


An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.


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1

Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan

2

Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Kanagawa 210-8681, Japan

3

R & D Planning Department, Ajinomoto Co., Inc., Chuo-ku, Tokyo 104-8315, Japan





*

Author to whom correspondence should be addressed.



Academic Editor: Yoshihide Usami

Abstract Three new compounds, enhygromic acid 1 and deoxyenhygrolides A 2 and B 3, were isolated from a marine myxobacterium, Enhygromyxa sp. Compound 1 was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds 2 and 3 were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound 1 exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity against Bacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells. View Full-Text

Keywords: marine myxobacterium; diterpene; NGF-enhancing activity; cytotoxicity; antibacterial activity marine myxobacterium; diterpene; NGF-enhancing activity; cytotoxicity; antibacterial activity





Autor: Tomohiko Tomura 1, Shiori Nagashima 1, Satoshi Yamazaki 1, Takashi Iizuka 2, Ryosuke Fudou 3 and Makoto Ojika 1,*

Fuente: http://mdpi.com/



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