Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79Reportar como inadecuado


Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79


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1

Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China

2

College of Earth Science, University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China





*

Author to whom correspondence should be addressed.



Academic Editors: Vítor Vasconcelos, Pedro Leão and Anake Kijjoa

Abstract Three new indolediterpenoids, namely, 22-hydroxylshearinine F 1, 6-hydroxylpaspalinine 2, and 7-O-acetylemindole SB 3, along with eight related known analogs 4–11, were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations 1 and 2 and single-crystal X-ray diffraction 3. Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes. View Full-Text

Keywords: endophytic fungus; Penicillium sp.; secondary metabolites; antimicrobial activity endophytic fungus; Penicillium sp.; secondary metabolites; antimicrobial activity





Autor: Xue-Yi Hu 1,2, Ling-Hong Meng 1, Xin Li 1, Sui-Qun Yang 1,2, Xiao-Ming Li 1 and Bin-Gui Wang 1,*

Fuente: http://mdpi.com/



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