Impact of Cell-Free Fetal DNA Screening on Patients’ Choice of Invasive Procedures after a Positive California Prenatal Screen ResultReportar como inadecuado




Impact of Cell-Free Fetal DNA Screening on Patients’ Choice of Invasive Procedures after a Positive California Prenatal Screen Result - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Cancer Genetics Department, Saint Joseph Hospital, Orange, CA 92868, USA

2

Department of Pediatrics Irvine, University of California, Orange, CA 92868, USA

3

San Diego and Rady Childrens Hospital, University of California, San Diego, CA 92037, USA

4

San Diego, Fetal Care & Genetics San Diego, University of California, CA 92037, USA



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract Until recently, maternal serum analyte levels paired with sonographic fetal nuchal translucency measurement was the most accurate prenatal screen available for Trisomies 18 and 21, 91% and 94% detection and false positive rates of 0.31% and 4.5% respectively. Women with positive California Prenatal Screening Program CPSP results have the option of diagnostic testing to determine definitively if the fetus has a chromosomal abnormality. Cell-free fetal cff- DNA screening for Trisomies 13, 18, and 21 was first offered in 2012, allowing women with positive screens to choose additional screening before diagnostic testing. Cff-DNA sensitivity rates are as high as 99.9% and 99.1%, with false positive rates of 0.4% and 0.1%, for Trisomies 18 and 21, respectively. A retrospective chart review was performed in 2012 on 500 CPSP referrals at the University of California, San Diego Thornton Hospital. Data were collected prior to and after the introduction of cff-DNA. There was a significant increase in the number of participants who chose to pursue additional testing and a decrease in the number of invasive procedures performed after cff-DNA screening was available. We conclude that as fetal aneuploidy screening improves, the number of invasive procedures will continue to decrease. View Full-Text

Keywords: prenatal; cell-free fetal DNA screening; non-invasive prenatal testing prenatal; cell-free fetal DNA screening; non-invasive prenatal testing





Autor: Forum T. Shah 1,* , Kathryn Steinhaus French 2,†, Kathryn E. Osann 2,†, Maureen Bocian 2,†, Marilyn C. Jones 3 and Lauren Korty 4

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados