Reducing Liver Fat by Low Carbohydrate Caloric Restriction Targets Hepatic Glucose Production in Non-Diabetic Obese Adults with Non-Alcoholic Fatty Liver DiseaseReportar como inadecuado




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1

Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth Peoples Hospital, Shanghai Diabetes Institute, Shanghai Clinical Centre of Diabetes, Shanghai 200233, China

2

Endocrine Research Unit, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Foundation, 5-194 Joseph, Rochester, MN 55905, USA





*

Author to whom correspondence should be addressed.



Abstract Non-alcoholic fatty liver disease NAFLD impairs liver functions, the organ responsible for the regulation of endogenous glucose production and thus plays a key role in glycemic homeostasis. Therefore, interventions designed to normalize liver fat content are needed to improve glucose metabolism in patients affected by NAFLD such as obesity. Objective: this investigation is designed to determine the effects of caloric restriction on hepatic and peripheral glucose metabolism in obese humans with NAFLD. Methods: eight non-diabetic obese adults were restricted for daily energy intake 800 kcal and low carbohydrate <10% for 8 weeks. Body compositions, liver fat and hepatic glucose production HGP and peripheral glucose disposal before and after the intervention were determined. Results: the caloric restriction reduced liver fat content by 2-3 p = 0.004. Abdominal subcutaneous and visceral fat, body weight, BMI, waist circumference and fasting plasma triglyceride and free fatty acid concentrations all significantly decreased p < 0.05. The suppression of post-load HGP was improved by 22% p = 0.002 whereas glucose disposal was not affected p = 0.3. Fasting glucose remained unchanged and the changes in the 2-hour plasma glucose and insulin concentration were modest and statistically insignificant p > 0.05. Liver fat is the only independent variable highly correlated to HGP after the removal of confounders. Conclusion: NAFLD impairs HGP but not peripheral glucose disposal; low carbohydrate caloric restriction effectively lowers liver fat which appears to directly correct the HGP impairment. View Full-Text

Keywords: obesity; caloric restriction; liver fat; hepatic glucose production; glucose disposal obesity; caloric restriction; liver fat; hepatic glucose production; glucose disposal





Autor: Haoyong Yu 1, Weiping Jia 1 and ZengKui Guo 2,*

Fuente: http://mdpi.com/



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