Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by PituitruinReportar como inadecuado




Effect of Salvianolic Acid b and Paeonol on Blood Lipid Metabolism and Hemorrheology in Myocardial Ischemia Rabbits Induced by Pituitruin - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Institute of Materia Medica, School of pharmacy; Fourth Military Medical University, Xian, Shaanxi, 7l0032, China

2

Department of Neurosurgery, XiJing Hospital, Fourth Military Medical University, Xian, Shaanxi, 7l0032, China





*

Author to whom correspondence should be addressed.



Abstract The purpose of this study was to determine the therapeutic effect of salvianolic acid b and paeonol on coronary disease. The ischemia myocardial animal model is induced by administering pituitrin 20 μg·kg−1 intravenously via the abdominal vein. A combination of salvianolic acid b and paeonol CSAP 5, 10 and 15 mg-kg BW was administrated to experimental rabbits. Biochemical indices were evaluated during six weeks of intervention. We found that the compound of salvianolic acid b and paeonol 5, 10 and 15 mg-kg BW can markedly and dose-dependently reduce fibrinogen and malonaldehyde levels, increase the HDL level, improve blood viscosity and plasma viscosity in rabbits. In addition, the medicine can still reduce the ratio of NO-ET and the contents of lactate dehydrogenase LDH and creatine phosphokinase CPK in a dose-dependent manner. This study demonstrates that compound of salvianolic acid b and paeonol 5, 10 and 15 mg-kg BW can improve the blood hemorrheology, decrease oxidative injury and repair the function of blood vessel endothelium, and subsequently prevent the development of Coronary disease. View Full-Text

Keywords: coronary disease; hemorrheology; lipid peroxidation; salvianolic acid b coronary disease; hemorrheology; lipid peroxidation; salvianolic acid b





Autor: Qian Yang 1, Siwang Wang 1,* , Yanhua Xie 1, Jianbo Wang 1, Hua Li 1, Xuanxuan Zhou 1 and Wenbo Liu 2

Fuente: http://mdpi.com/



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