Three-Dimensional Models of the Oligomeric Human Asialoglycoprotein Receptor ASGP-RReportar como inadecuado




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1

UdR INSTM, Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

2

Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications BIOlab-UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, 56010 S. Piero a Grado, Pisa, Italy

3

Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy





*

Author to whom correspondence should be addressed.



Abstract The work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor ASGP-R, by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds H1 and H2, which are highly homologous. Its stoichiometry is still unknown. An articulated step-wise modeling protocol was used in order to build the receptor model in a minimal oligomeric form, necessary for it to bind multi-antennary carbohydrate ligands. The ultimate target of the study is to contribute to increasing the knowledge of interactions between the human ASGP-R and carbohydrate ligands, at the molecular level, pertinent to applications in the field of hepatic tissue engineering. View Full-Text

Keywords: ASGP-R; oligomeric form; antennary carbohydratic ligands ASGP-R; oligomeric form; antennary carbohydratic ligands





Autor: Ilaria Massarelli 1, Federica Chiellini 2, Emo Chiellini 2 and Anna Maria Bianucci 3,*

Fuente: http://mdpi.com/



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