Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of OsteoarthritisReportar como inadecuado




Efficacy of Intra-Articular Injection of Celecoxib in a Rabbit Model of Osteoarthritis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, 188 Shizi St., Suzhou, Jiangsu 215006, China



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract Introduction: Osteoarthritis is the most common form of arthritis. It is a slowly progressive joint disease typically seen in middle-age to elderly people. Intra-articular injection of hyaluronic acid is a well-documented treatment for knee osteoarthritis. Celebrex® celecoxib is a novel nonsteroidal anti-inflammatory drug, which could help to reduce inflammation and to reduce pain. The aim of this study was to evaluate the effects of intra-articular injection of celecoxib in a rabbit osteoarthritis model. Methods: Thirty New Zealand white rabbits underwent unilateral knee joint surgery using the Hulth technique. Six weeks post-surgery, the animals were randomly divided into three groups, and each group was respectively given weekly intra-articular injections with Celebrex®, hyaluronic acid and saline. On the sixth week, the results were assessed in rabbit models by gross observation, histological evaluation, and expression of IL-1β, TNF-α, MMP-3. Results: In the group given Celebrex® and hyaluronic acid, the pathological changes in the rabbit articular cartilage improved significantly, much more than in the saline group. The statistically significant suppression of IL-1β, TNF-α, MMP-3 was shown in the Celebrex group. No significant differences were detected between two treatment groups. Conclusions: Intra-articular injection of celecoxib is beneficial for knee osteoarthritis. It might repair and protect early osteoarthritis cartilage by delaying cartilage degeneration and impairing the function of inflammatory mediators, therefore, intra-articular injection of celecoxib can be used as an alternative to the current treatment of osteoarthritis. View Full-Text

Keywords: celecoxib; hyaluronic acid; intra-articular injection; osteoarthritis celecoxib; hyaluronic acid; intra-articular injection; osteoarthritis





Autor: Dinghua Jiang †, Jun Zou †, Lixin Huang * , Qin Shi, Xuesong Zhu, Genlin Wang and Huilin Yang

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados