Involvement of Glutamate Transporter-1 in Neuroprotection against Global Brain Ischemia-Reperfusion Injury Induced by Postconditioning in RatsReportar como inadecuado




Involvement of Glutamate Transporter-1 in Neuroprotection against Global Brain Ischemia-Reperfusion Injury Induced by Postconditioning in Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

2

Department of Neurosurgery, YuYao People’s Hospital, Zhejiang Province, 315400, China





*

Author to whom correspondence should be addressed.



Abstract Ischemic postconditioning refers to several transient reperfusion and ischemia cycles after an ischemic event and before a long duration of reperfusion. The procedure produces neuroprotective effects. The mechanisms underlying these neuroprotective effects are poorly understood. In this study, we found that most neurons in the CA1 region died after 10 minutes of ischemia and is followed by 72 hours of reperfusion. However, brain ischemic postconditioning six cycles of 10 s-10 s reperfusion-re-occlusion significantly reduced neuronal death. Significant up-regulation of Glutamate transporter-1 was found after 3, 6, 24, 72 hours of reperfusion. The present study showed that ischemic postconditioning decreases cell death and that upregulation of GLT-1 expression may play an important role on this effect. View Full-Text

Keywords: ischemic postconditioning; brain ischemia reperfusion injury; neuroprotection; glutamate transporter 1GLT-1 ischemic postconditioning; brain ischemia reperfusion injury; neuroprotection; glutamate transporter 1GLT-1





Autor: Weiqiao Zhang 1,2, Yifeng Miao 1, Sanquan Zhou 2, Baofeng Wang 1, Qizhong Luo 1 and Yongming Qiu 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados