Synthesis and Antibacterial Activities of 1-Alkyl-3-methacryloyl Acryloyl of Benzimidazolone Thione DerivativesReportar como inadecuado




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College of plant protection and Institute of Pesticide Science, Northwest A & F University, Shaanxi 712100, China





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Abstract A series of 28 1-alkyl-3-methacryloyl acryloyl-benzimidazolone thione deriv-atives were synthesized. The structures of the new derivatives were confirmed by 1H-NMR, 13C-NMR and ESI-MS spectral analysis. The antibacterial activities of these compounds against several strains of bacteria, such as Bacillus cereus, Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, were evaluated by methods of paper disc-diffusion and broth mciro-dilution. Methacryloyl derivatives displayed higher antibacterial activities against tested bacterial strains than those of acryloyl derivatives in in vitro tests. A structure-activity relationship SAR study revealed that the presences of the methacryloyl moieties is essential to the antibacterial activities of the compounds. View Full-Text

Keywords: benzimidazolone thione derivatives; synthesis; antibacterial activity benzimidazolone thione derivatives; synthesis; antibacterial activity





Autor: Shaopeng Wei, Wenjun Wu and Zhiqin Ji *

Fuente: http://mdpi.com/



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