Aristolactam-Type Alkaloids from Orophea enterocarpa and Their CytotoxicitiesReportar como inadecuado




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1

Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand

2

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand

3

Department of Chemistry, Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 53000, Thailand

4

The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10220, Thailand





*

Author to whom correspondence should be addressed.



Abstract A new aristolactam, named enterocarpam-III 10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1 together with the known alkaloid stigmalactam 2, were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma HCT15 cell line with IC50 values of 1.68 and 1.32 μM, respectively. View Full-Text

Keywords: Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities Orophea enterocarpa; Anonaceae; aristolactam; human colon adenocarcinoma cells; cytotoxicities





Autor: Sanchai Nayyatip 1, Pak Thaichana 2, Mongkol Buayairaksa 1, Wirote Tuntiwechapikul 2, Puttinan Meepowpan 3, Narong Nuntasaen 4 and Wilart Pompimon 1,*

Fuente: http://mdpi.com/



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