X-Ray Repair Cross Complementing Protein 1 in Base Excision RepairReportar como inadecuado




X-Ray Repair Cross Complementing Protein 1 in Base Excision Repair - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway

2

Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 N, Denmark





*

Author to whom correspondence should be addressed.



Abstract X-ray Repair Cross Complementing protein 1 XRCC1 acts as a scaffolding protein in the converging base excision repair BER and single strand break repair SSBR pathways. XRCC1 also interacts with itself and rapidly accumulates at sites of DNA damage. XRCC1 can thus mediate the assembly of large multiprotein DNA repair complexes as well as facilitate the recruitment of DNA repair proteins to sites of DNA damage. Moreover, XRCC1 is present in constitutive DNA repair complexes, some of which associate with the replication machinery. Because of the critical role of XRCC1 in DNA repair, its common variants Arg194Trp, Arg280His and Arg399Gln have been extensively studied. However, the prevalence of these variants varies strongly in different populations, and their functional influence on DNA repair and disease remains elusive. Here we present the current knowledge about the role of XRCC1 and its variants in BER and human disease-cancer. View Full-Text

Keywords: BER; XRCC1; disease; DNA damage; polymorphisms; recruitment; repair complex; scaffold BER; XRCC1; disease; DNA damage; polymorphisms; recruitment; repair complex; scaffold





Autor: Audun Hanssen-Bauer 1, Karin Solvang-Garten 1, Mansour Akbari 2 and Marit Otterlei 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados