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1

INSERM UMR-1037 Université de Toulouse, Centre de Recherche en Cancérologie de Toulouse CRCT and Laboratoire dExcellence Toulouse Cancer, TOUCAN, Toulouse 31432, France

2

Centre Hospitalier de Toulouse, Pôle Digestif, Toulouse 31432, France





*

Author to whom correspondence should be addressed.



Abstract In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival or completion of apoptosis when cells are exposed to severe or prolonged stress. In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated. View Full-Text

Keywords: translation initiation; eIF2; eIF4F; 4E-BPs; apoptosis; uORF; IRES translation initiation; eIF2; eIF4F; 4E-BPs; apoptosis; uORF; IRES





Autor: Charline Lasfargues 1, Yvan Martineau 1, Corinne Bousquet 1 and Stéphane Pyronnet 1,2,*

Fuente: http://mdpi.com/



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