An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated DiseasesReportar como inadecuado




An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1

Department of Pharmacology, School of Medicine, Chonbuk National Univeristy, Jeonju 561-180, South Korea

2

Department of Dental Pharmacology, Dental School, Wonkwang University, Iksan 570-749, South Korea





*

Authors to whom correspondence should be addressed.



Abstract The endoplasmic reticulum ER is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to the predominant disulfide bond formation during the process of protein folding. Alterations in the oxidative environment of the ER and also intra-ER Ca2+ cause the production of ER stress-induced reactive oxygen species ROS. Protein disulfide isomerases, endoplasmic reticulum oxidoreductin-1, reduced glutathione and mitochondrial electron transport chain proteins also play crucial roles in ER stress-induced production of ROS. In this article, we discuss ER stress-associated ROS and related diseases, and the current understanding of the signaling transduction involved in ER stress. View Full-Text

Keywords: ER stress; ER stress associated disease; ER associated oxidative stress; disulfide bond formation; PDI; ERO-1α; mitochondria electron transport chain ER stress; ER stress associated disease; ER associated oxidative stress; disulfide bond formation; PDI; ERO-1α; mitochondria electron transport chain





Autor: Bidur Bhandary 1, Anu Marahatta 1, Hyung-Ryong Kim 2,* and Han-Jung Chae 1,*

Fuente: http://mdpi.com/



DESCARGAR PDF




Documentos relacionados