Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory ActivityReportar como inadecuado




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1

Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan

2

Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan

3

Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan

4

Department of Pharmacy, China Medical University, Taichung 40402, Taiwan

5

Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan

6

Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan



These authors contributed equally to this work.





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Author to whom correspondence should be addressed.



Abstract Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2-oxygenated flavonoids 1 and 2, two new phenyl glycosides 3 and 4, along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, 1–2 and 6–19 were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed. View Full-Text

Keywords: Andrographis echioides; flavonoid; anti-inflammatory; iNOS Andrographis echioides; flavonoid; anti-inflammatory; iNOS





Autor: De-Yang Shen 1,†, Shin-Hun Juang 2,†, Ping-Chung Kuo 3,†, Guan-Jhong Huang 4, Yu-Yi Chan 5, Amooru G. Damu 1 and Tian-Shung Wu 1,4,6,*

Fuente: http://mdpi.com/



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