Quorum Quenching Enzymes and Their Application in Degrading Signal Molecules to Block Quorum Sensing-Dependent InfectionReportar como inadecuado




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School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China



These authors contributed equally to this work.





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Abstract With the emergence of antibiotic-resistant strains of bacteria, the available options for treating bacterial infections have become very limited, and the search for a novel general antibacterial therapy has received much greater attention. Quorum quenching can be used to control disease in a quorum sensing system by triggering the pathogenic phenotype. The interference with the quorum sensing system by the quorum quenching enzyme is a potential strategy for replacing traditional antibiotics because the quorum quenching strategy does not aim to kill the pathogen or limit cell growth but to shut down the expression of the pathogenic gene. Quorum quenching enzymes have been identified in quorum sensing and non-quorum sensing microbes, including lactonase, acylase, oxidoreductase and paraoxonase. Lactonase is widely conserved in a range of bacterial species and has variable substrate spectra. The existence of quorum quenching enzymes in the quorum sensing microbes can attenuate their quorum sensing, leading to blocking unnecessary gene expression and pathogenic phenotypes. In this review, we discuss the physiological function of quorum quenching enzymes in bacterial infection and elucidate the enzymatic protection in quorum sensing systems for host diseases and their application in resistance against microbial diseases. View Full-Text

Keywords: quorum sensing; quorum quenching; lactonase; acylase; acyl homoserine lactone; specificity quorum sensing; quorum quenching; lactonase; acylase; acyl homoserine lactone; specificity





Autor: Fang Chen †, Yuxin Gao †, Xiaoyi Chen, Zhimin Yu and Xianzhen Li *

Fuente: http://mdpi.com/



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