Materials Characterization of Feraheme-Ferumoxytol and Preliminary Evaluation of Its Potential for Magnetic Fluid HyperthermiaReportar como inadecuado




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1

Department of Materials Science & Engineering, University of Florida, Gainesville, FL 32611-6400, USA

2

Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA

3

Institute for Cell Engineering and Regenerative Medicine, University of Florida, Gainesville, FL 32611-6131, USA





*

Author to whom correspondence should be addressed.



Abstract Feraheme, is a recently FDA-cleared superparamagnetic iron oxide nanoparticle SPION-based MRI contrast agent that is also employed in the treatment of iron deficiency anemia. Feraheme nanoparticles have a hydrodynamic diameter of 30 nm and consist of iron oxide crystallites complexed with a low molecular weight, semi-synthetic carbohydrate. These features are attractive for other potential biomedical applications such as magnetic fluid hyperthermia MFH, since the carboxylated polymer coating affords functionalization of the particle surface and the size allows for accumulation in highly vascularized tumors via the enhanced permeability and retention effect. This work presents morphological and magnetic characterization of Feraheme by transmission electron microscopy TEM, Energy dispersive X-ray spectroscopy EDX, and superconducting quantum interference device SQUID magnetometry. Additionally, the results of an initial evaluation of the suitability of Feraheme for MFH applications are described, and the data indicate the particles possess promising properties for this application. View Full-Text

Keywords: Feraheme; magnetic fluid hyperthermia; magnetic nanoparticles; MRI contrast Feraheme; magnetic fluid hyperthermia; magnetic nanoparticles; MRI contrast





Autor: John P. Bullivant 1, Shan Zhao 1, Brad J. Willenberg 1, Bettina Kozissnik 2,3, Christopher D. Batich 1,3 and Jon Dobson 1,2,3,*

Fuente: http://mdpi.com/



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