Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs NSAIDs and Mesalazine in the Chemoprevention of Colorectal CancerReportar como inadecuado




Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs NSAIDs and Mesalazine in the Chemoprevention of Colorectal Cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Department of Systems Medicine, University of Tor Vergata, Via Montpellier 1, Rome 00133, Italy





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Abstract Colorectal cancer CRC is the third most common malignant neoplasm worldwide. Although conclusive evidence is still lacking, epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs NSAIDs has chemopreventive properties against CRC. Similarly, regular consumption of mesalazine, a drug structurally related to NSAIDs, seems to reduce the risk of CRC in patients with ulcerative colitis. These observations are supported by a large body of experimental data showing the ability of such drugs to inhibit multiple pathways that sustain colon carcinogenesis. This review summarizes the current information on the molecular mechanisms by which NSAIDs and mesalazine could interfere with CRC cell growth and survival. View Full-Text

Keywords: aspirin; non-steroidal anti-inflammatory drugs; 5-aminosalicylic acid; cyclooxygenase; prostaglandins; colitis-associated colon cancer; carcinogenesis; Wnt-β-catenin; cell cycle; DNA replication fidelity aspirin; non-steroidal anti-inflammatory drugs; 5-aminosalicylic acid; cyclooxygenase; prostaglandins; colitis-associated colon cancer; carcinogenesis; Wnt-β-catenin; cell cycle; DNA replication fidelity





Autor: Carmine Stolfi * , Veronica De Simone, Francesco Pallone and Giovanni Monteleone *

Fuente: http://mdpi.com/



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