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School of Biology and Environmental Science & Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland





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Abstract The Golgi complex lies at the heart of the secretory pathway and is responsible for modifying proteins and lipids, as well as sorting newly synthesized molecules to their correct destination. As a consequence of these important roles, any changes in its proteome can negatively affect its function and in turn lead to disease. Recently, a number of proteins have been identified, which when either depleted or mutated, result in diseases that affect various organ systems. Here we describe how these proteins have been linked to the Golgi complex, and specifically how they affect either the morphology, membrane traffic or glycosylation ability of this organelle. View Full-Text

Keywords: Golgi complex; intracellular trafficking; membrane traffic; protein glycosylation; disease Golgi complex; intracellular trafficking; membrane traffic; protein glycosylation; disease





Autor: Mariana G. Bexiga and Jeremy C. Simpson *

Fuente: http://mdpi.com/



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