Synthesis of Cellulose-2,3-bis3,5-dimethylphenylcarbamate in an Ionic Liquid and Its Chiral Separation Efficiency as Stationary PhaseReportar como inadecuado




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1

College of Plant Protection, Hunan Agricultural University, Changsha 410128, China

2

College of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China

3

Hunan Academy of Agricultural Sciences, Changsha 410125, China





*

Authors to whom correspondence should be addressed.



Abstract A chiral selector of cellulose-2,3-bis3,5-dimethylphenylcarbamate CBDMPC was synthesized by reacting 3,5-dimethylphenyl isocyanate with microcrystalline cellulose dissolved in an ionic liquid of 1-allyl-3-methyl-imidazolium chloride AMIMCl. The obtained chiral selector was effectively characterized by infrared spectroscopy, elemental analysis and 1H NMR. The selector was reacted with 3-aminopropylsilanized silica gel and the CBDMPC bonded chiral stationary phase CSP was obtained. Chromatographic evaluation of the prepared CSPs was conducted by high performance liquid chromatographic HPLC and baseline separation of three typical fungicides including hexaconazole, metalaxyl and myclobutanil was achieved using n-hexane-isopropanol as the mobile phase with a flow rate 1.0 mL-min. Experimental results also showed that AMIMCl could be recycled easily and reused in the preparation of CSPs as an effective reaction media. View Full-Text

Keywords: 1-allyl-3-methyl-imidazolium chloride; synthesis; Cellulose-2,3-bis3,5-dimethylphenylcarbamate; high performance liquid chromatography; chiral stationary phase; enantioseparation 1-allyl-3-methyl-imidazolium chloride; synthesis; Cellulose-2,3-bis3,5-dimethylphenylcarbamate; high performance liquid chromatography; chiral stationary phase; enantioseparation





Autor: Runqiang Liu 1,2, Yijun Zhang 2, Lianyang Bai 1,3,* , Mingxian Huang 2, Jun Chen 2 and Yuping Zhang 2,*

Fuente: http://mdpi.com/



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