The Reliability and Predictive Ability of a Biomarker of Oxidative DNA Damage on Functional Outcomes after Stroke RehabilitationReportar como inadecuado




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1

Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

2

Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan

3

School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei 100, Taiwan

4

Division of Occupational Therapy, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei 100, Taiwan

5

Stroke Center and Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

6

Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei 100, Taiwan





*

Author to whom correspondence should be addressed.



Abstract We evaluated the reliability of 8-hydroxy-2-deoxyguanosine 8-OHdG, and determined its ability to predict functional outcomes in stroke survivors. The rehabilitation effect on 8-OHdG and functional outcomes were also assessed. Sixty-one stroke patients received a 4-week rehabilitation. Urinary 8-OHdG levels were determined by liquid chromatography–tandem mass spectrometry. The test-retest reliability of 8-OHdG was good interclass correlation coefficient = 0.76. Upper-limb motor function and muscle power determined by the Fugl-Meyer Assessment FMA and Medical Research Council MRC scales before rehabilitation showed significant negative correlation with 8-OHdG r = −0.38, r = −0.30; p < 0.05. After rehabilitation, we found a fair and significant correlation between 8-OHdG and FMA r = −0.34 and 8-OHdG and pain r = 0.26, p < 0.05. Baseline 8-OHdG was significantly correlated with post-treatment FMA, MRC, and pain scores r = −0.34, −0.31, and 0.25; p < 0.05, indicating its ability to predict functional outcomes. 8-OHdG levels were significantly decreased, and functional outcomes were improved after rehabilitation. The exploratory study findings conclude that 8-OHdG is a reliable and promising biomarker of oxidative stress and could be a valid predictor of functional outcomes in patients. Monitoring of behavioral indicators along with biomarkers may have crucial benefits in translational stroke research. View Full-Text

Keywords: oxidative stress; stroke; rehabilitation; biomarker; 8-OHdG; clinical evaluation oxidative stress; stroke; rehabilitation; biomarker; 8-OHdG; clinical evaluation





Autor: Yu-Wei Hsieh 1,2, Keh-Chung Lin 3,4, Mallikarjuna Korivi 1,2, Tsong-Hai Lee 5, Ching-Yi Wu 1,2,* and Kuen-Yuh Wu 6

Fuente: http://mdpi.com/



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