Towards Personalized Medicine Mediated by in Vitro Virus-Based Interactome ApproachesReportar como inadecuado




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Division of Interactome Medical Sciences, the Institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan





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Abstract We have developed a simple in vitro virus IVV selection system based on cell-free co-translation, using a highly stable and efficient mRNA display method. The IVV system is applicable to the high-throughput and comprehensive analysis of proteins and protein–ligand interactions. Huge amounts of genomic sequence data have been generated over the last decade. The accumulated genetic alterations and the interactome networks identified within cells represent a universal feature of a disease, and knowledge of these aspects can help to determine the optimal therapy for the disease. The concept of the -integrome- has been developed as a means of integrating large amounts of data. We have developed an interactome analysis method aimed at providing individually-targeted health care. We also consider future prospects for this system. View Full-Text

Keywords: cell-free protein synthesis system; in vitro selection; in vitro virus; protein-protein interaction cell-free protein synthesis system; in vitro selection; in vitro virus; protein-protein interaction





Autor: Hiroyuki Ohashi and Etsuko Miyamoto-Sato *

Fuente: http://mdpi.com/



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