Design, Synthesis and Bioactivity of N-Glycosyl-N-5-substituted phenyl-2-furoyl Hydrazide DerivativesReportar como inadecuado




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1

Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China

2

Division of Nanobiology, Advanced Integrated Science, Chiba University, Matsudo, Chiba 271-0092, Japan

3

Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China

4

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China





*

Authors to whom correspondence should be addressed.



Abstract Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides d-glucose, d-galactose, d-mannose, d-fucose and d-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by 1H NMR spectroscopy. The results showed that, except for the d-glucose derivatives, which were in the presence of β-anomeric forms, all derivatives were in an acyclic Schiff base form. Their antifungal and antitumor activities were studied. The bioassay results indicated that some title compounds showed superior effects over the commercial positive controls. View Full-Text

Keywords: glycosylhydrazide; synthesis; tautomer; antifungal activity; antitumor activity glycosylhydrazide; synthesis; tautomer; antifungal activity; antitumor activity





Autor: Zining Cui 1,2,4,* , Hang Su 3, Jiazhen Jiang 3,* , Xinling Yang 3 and Yoshihiro Nishida 2

Fuente: http://mdpi.com/



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