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1

Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Korea

2

Catholic Kwandong University International St. Marys Hospital, Incheon Metropolitan City 404-834, Korea



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract Atrial fibrillation AF has been recognized as a major cause of cardiovascular-related morbidity and mortality. MicroRNAs miRNAs represent recent additions to the collection of biomolecules involved in arrhythmogenesis. Reactive oxygen species ROS have been independently linked to both AF and miRNA regulation. However, no attempts have been made to investigate the possibility of a framework composed of ROS–miRNA–AF that is related to arrhythmia development. Therefore, this review was designed as an attempt to offer a new approach to understanding AF pathogenesis. The aim of this review was to find and to summarize possible connections that exist among AF, miRNAs and ROS to understand the interactions among the molecular entities underlying arrhythmia development in the hopes of finding unappreciated mechanisms of AF. These findings may lead us to innovative therapies for AF, which can be a life-threatening heart condition. A systemic literature review indicated that miRNAs associated with AF might be regulated by ROS, suggesting the possibility that miRNAs translate cellular stressors, such as ROS, into AF pathogenesis. Further studies with a more appropriate experimental design to either prove or disprove the existence of an ROS–miRNA–AF framework are strongly encouraged. View Full-Text

Keywords: atrial fibrillation AF; reactive oxygen species ROS; miRNA; arrhythmia atrial fibrillation AF; reactive oxygen species ROS; miRNA; arrhythmia





Autor: Seahyoung Lee 1,2,†, Eunhyun Choi 1,2,†, Min-Ji Cha 1,2 and Ki-Chul Hwang 1,2,*

Fuente: http://mdpi.com/



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